Vertical decorative line
Research Center for Complex Molecular Systems and Biomolecules
Center for Biomolecules and Complex Molecular Systems   
Supported by the Ministry of Education, Czech Republic      
Decorative element
Decorative element
Decorative element Research | Papers | People | Events | Archive | Teach | Contact   
Decorative element
Empty gif
Empty space gif.
Abstract of the article
Empty gif Empty gif
Helicity control in the synthesis of helicenes and related compounds.

Stary, I.; Stara, I.; Alexandrova, Z. etc., Pure and Applied Chemistry, 78 [2] 495 - 499 (2006)

Asymmetric synthesis of helicenes and their congeners has been demonstrated to rely either on enantioselective Ni-0/PR3*-catalyzed [2+2+2] cycloisomerization of triynes or on diastereoselective Co-I-catalyzed [2+2+2] cycloisomerization of chiral triynes. The former approach providing tetrahydrohelicenes in a nonracemic form requires further development as moderate enantioselectivities (up to 54 % ee) have so far been achieved under kinetic control. The latter approach affording helicene-like structures in a diastereomerically enriched form allows for reaching good to excellent diastereoselectivities (up to 100:0) under thermodynamic control.


<< Go back
Empty space gif.
Empty gif
Decorative element