A new modular and practical methodology for the synthesis of 4- or 3- substituted phenyl C-nucleosides.
Hocek, M.; Pohl, R.; Klepetarova, B.,
, 21 4525 - 4528 (2005)
A novel efficient and practical approach to the synthesis of 4-or 3-substituted phenyl C-nucleosides has been developed. It consists in coupling of protected halogenose 1 with bromophenylmagnesium bromides followed by acid mediated epimerization to prepare 4- or 3-bromophenyl C-nucleoside intermediates. Their Pd-catalyzed cross-coupling reactions with diverse organometallics followed by deprotection afforded the title nucleoside analogues.