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Research Center for Complex Molecular Systems and Biomolecules
Center for Biomolecules and Complex Molecular Systems   
Supported by the Ministry of Education, Czech Republic      
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Abstract of the article
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A new modular and practical methodology for the synthesis of 4- or 3- substituted phenyl C-nucleosides.

Hocek, M.; Pohl, R.; Klepetarova, B., , 21 4525 - 4528 (2005)

A novel efficient and practical approach to the synthesis of 4-or 3-substituted phenyl C-nucleosides has been developed. It consists in coupling of protected halogenose 1 with bromophenylmagnesium bromides followed by acid mediated epimerization to prepare 4- or 3-bromophenyl C-nucleoside intermediates. Their Pd-catalyzed cross-coupling reactions with diverse organometallics followed by deprotection afforded the title nucleoside analogues.


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